Publications

Peer-reviewed

• Developmental assembly of contractile actomyosin networks in the C. elegans spermatheca requires anillin and successful cytokinesis (2026)

  Co-first author paper and cover article showing that successful cytokinesis is required for the developmental assembly of contractile actomyosin networks in the C. elegans spermatheca, identifying anillin as a key regulator linking early cell division to later tissue architecture and organ contractility.

  Development · Fung-Yi Chan , Daniel Osório , Catarina Pereira , Mafalda Cautela , Hugo Silva , Maurizio Gilioli , Ines Loureiro , Ana Beatriz Dias , Reto Gassmann , Ana Xavier Carvalho

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• Src-dependent tyrosine-phosphorylation of NM2A has a protective role against bacterial pore-forming toxins (2026)

  Shows that bacterial pore-forming toxins trigger Src-dependent phosphorylation of NM2A, promoting cytoskeletal remodeling and a conserved protective response to plasma membrane damage.

  PLoS Pathogens · Cláudia Brito , Francisco S. Mesquita , Joana M. Pereira , Daniel S. Osório , Neil Billington , Ricardo R. Lima , Sílvia Vale-Costa , James R. Sellers , Didier Cabanes , Ana X. Carvalho , Sandra Sousa

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• Anillin forms linear structures and facilitates furrow ingression after septin and formin depletion (2023)

  Cell Reports · Lebedev, M. , Chan, F.-Y. , Lochner, A. , Bellessem, J. , Osório, D.S. , Rackles, E. , Mikeladze-Dvali, T. , Carvalho, A.X. , Zanin, E.

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• Ctdnep1 and Eps8L2 regulate dorsal actin cables for nuclear positioning during cell migration (2021)

  Identifies Ctdnep1 and Eps8L2 as regulators of dorsal actin cable organization required for proper nuclear positioning during cell migration.

  Current Biology · Calero-Cuenca, F.J. , Osório, D.S. , Carvalho-Marques, S. , Sridhara, S.C. , Oliveira, L.M. , Jiao, Y. , Diaz, J. , Janota, C.S. , Cadot, B. , Gomes, E.R.

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• Plastin and spectrin cooperate to stabilize the actomyosin cortex during cytokinesis (2021)

  Current Biology · Sobral, A.F. , Chan, F.-Y. , Norman, M.J. , Osório, D.S. , Dias, A.B. , Ferreira, V. , Barbosa, D.J. , Cheerambathur, D. , Gassmann, R. , Belmonte, J.M. , Carvalho, A.X.

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• Dullard-mediated Smad1/5/8 inhibition controls mouse cardiac neural crest cells condensation and outflow tract septation (2020)

  eLife · Jean-François Darrigrand , Mariana Valente , Glenda Comai , Pauline Martinez , Maxime Petit , Ryuichi Nishinakamura , Daniel Sampaio Osorio , Renault Gilles , Carmen Marchiol , Vanessa Ribes , Bruno Cadot

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• Equatorial Non-muscle Myosin II and Plastin Cooperate to Align and Compact F-actin Bundles in the Cytokinetic Ring (2020)

  Frontiers in Cell and Developmental Biology · Leite, J. , Chan, F.-Y. , Osório, D.S. , Saramago, J. , Sobral, A.F. , Silva, A.M. , Gassmann, R. , Carvalho, A.X.

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• PIG-1 MELK-dependent phosphorylation of nonmuscle myosin II promotes apoptosis through CES-1 Snail partitioning (2020)

  PLOS Genetics · Hai Wei , Eric J. Lambie , Daniel S. Osório , Ana X. Carvalho , Barbara Conradt

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• Crosslinking activity of non-muscle myosin II is not sufficient for embryonic cytokinesis in C. elegans (2019)

  Shows that myosin II crosslinking activity alone is not enough to drive embryonic cytokinesis in C. elegans, clarifying the mechanical requirements for contractile ring function.

  Development · Daniel S. Osório , Fung-Yi Chan , Joana Saramago , Joana Leite , Ana M. Silva , Ana F. Sobral , Reto Gassmann , Ana Xavier Carvalho

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• Network Contractility during Cytokinesis—From Molecular to Global Views (2019)

  Biomolecules · Leite, Joana , Osorio, Daniel Sampaio , Sobral, Ana Filipa , Silva, Ana Marta , Carvalho, Ana Xavier

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• TPXL-1 activates Aurora A to clear contractile ring components from the polar cortex during cytokinesis (2018)

  The Journal of Cell Biology · Sriyash Mangal , Jennifer Sacher , Taekyung Kim , Daniel Sampaio Osório , Fumio Motegi , Ana Xavier Carvalho , Karen Oegema , Esther Zanin

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• Emerging Mechanisms and Roles for Asymmetric Cytokinesis (2017)

  International Review of Cell and Molecular Biology · Thieleke-Matos, C. , Osório, D.S. , Carvalho, A.X. , Morais-de-Sá, E.

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• Robust gap repair in the contractile ring ensures timely completion of cytokinesis (2016)

  Demonstrates that the cytokinetic contractile ring can repair local gaps, ensuring robust ring closure and timely completion of cell division.

  Journal of Cell Biology · Silva, A.M. , Osório, D.S. , Pereira, A.J. , Maiato, H. , Pinto, I.M. , Rubinstein, B. , Gassmann, R. , Telley, I.A. , Carvalho, A.X.

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• Connecting the nucleus to the cytoskeleton for nuclear positioning and cell migration (2014)

  Advances in Experimental Medicine and Biology · Osorio, D.S. , Gomes, E.R.

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• The contemporary nucleus: A trip down memory lane (2013)

  Review article on the nucleus, revisiting its structural organization, dynamic connections to the cytoskeleton, and evolving roles in cell biology.

  Biology of the Cell · Osorio, D.S. , Gomes, E.R.

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• Samp1 is a component of TAN lines and is required for nuclear movement (2012)

  Shows that Samp1 is a component of TAN lines and is required for actin-dependent nuclear movement, linking the nuclear envelope to cytoskeletal force transmission.

  Journal of Cell Science · Borrego-Pinto, J. , Jegou, T. , Osorio, D.S. , Auradé, F. , Gorjánácz, M. , Koch, B. , Mattaj, I.W. , Gomes, E.R.

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• Structural and functional implications of positive selection at the primate angiogenin gene (2007)

  BMC Evolutionary Biology · Osorio, D.S. , Antunes, A. , Ramos, M.J.

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